Pentoxifylline


Generic Medicine Info
Administration
Should be taken with food.
Contraindications
Hypersensitivity to pentoxifylline, other methyl xanthines. Cerebral and extensive retinal haemorrhage, acute MI, severe cardiac arrhythmias.
Special Precautions
Patient w/ risk factors complicated by haemorrhage (e.g. recent surgery, peptic ulceration, cerebral and/or retinal bleeding), cerebrovascular disease, hypotension, severe coronary artery disease. Renal and severe hepatic impairment. Pregnancy and lactation. Monitoring Parameters Monitor prothrombin time, Hb, haematocrit. Monitor renal function.
Adverse Reactions
Significant: Anaphylactic reaction, angina, transient hypotension, reduction in coronary artery perfusion, arrhythmia. Nervous: Headache, dizziness, tremor, nervousness, drowsiness, insomnia, agitation, sleep disorder. CV: Tachycardia, flushing. GI: Nausea, vomiting, epigastric discomfort, abdominal distention, constipation, diarrhoea, dyspepsia, hypersalivation. Resp: Bronchospasm. Hepatic: Increased transaminases, cholestasis. Haematologic: Thrombocytopenia, leukopenia/neutropenia, haemorrhage. Ophthalmologic: Blurred vision. Dermatologic: Rash, erythema, pruritus, urticaria.
Drug Interactions
Increased exposure and toxicity w/ cimetidine, ciprofloxacin. Increased risk of bleeding and prolonged prothrombin time w/ anticoagulants (e.g. warfarin), platelet aggregation inhibitors (e.g. clopidogrel), and ketorolac. May increase theophylline levels and toxicity. Increased pharmacological effects of antihypertensive agents, insulin and oral hypoglycaemic agents.
CIMS Class
ATC Classification
C04AD03 - pentoxifylline ; Belongs to the class of purine derivative agents. Used as peripheral vasodilators.
Disclaimer: This information is independently developed by CIMS based on pentoxifylline from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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