Pilocarpine


Generic Medicine Info
Administration
May be taken with or without food.
Contraindications
Conditions where pupillary constriction is undesirable (e.g. acute iritis, acute uveitis, anterior uveitis and some forms of secondary glaucoma); acute inflammatory disease of the anterior segment. Clinically significant uncontrolled cardiorenal disease, uncontrolled asthma, COPD and other chronic disease at risk for cholinergic agonists.
Special Precautions
Patient w/ history of retinal detachment, corneal or conjunctival damage; cognitive or psychiatric disorders, epilepsy, Parkinson's disease; cholelithiasis or biliary tract disorders, hyperthyroidism; CV disease (e.g. HTN, hypotension); GI spasm, peptic ulceration; nephrolithiasis; resp disorders (e.g. controlled asthma, chronic bronchitis). Patients who are known to sweat excessively and who cannot drink enough liq. Hepatic or renal impairment. Pregnancy and lactation. Patient Counselling Not to be used in patients wearing soft contact lenses. This drug may cause miosis which may lead to blurred vision and difficulty w/ dark adaptation, do not drive or undertake hazardous tasks in poor illumination. Monitoring Parameters Monitor intraocular pressure. Perform funduscopic exam, visual field testing when necessary.
Adverse Reactions
Ophth: Blurred vision, browache, ciliary spasm, conjunctival vascular congestion, lens changes, myopia, ocular burning and itching, vitreous haemorrhage, pupillary block, smarting. Oral: Influenza-like symptoms, rhinitis, conjunctivitis, constipation, diarrhoea, nausea, vomiting, flatulence, dyspepsia, dizziness, flushing, headache, HTN, palpitation, increased urinary frequency and urgency, lacrimation, pruritus, rash, sweating.
Drug Interactions
Conduction disturbances w/ β-blockers. Concomitant admin of 2 miotics may increase risk of toxic reactions. Concurrent admin w/ drugs w/ parasympathomimetic effects may result in additive pharmacologic effects. May antagonise anticholinergic effects of atropine, inhaled ipratropium.
CIMS Class
Antiglaucoma Preparations
ATC Classification
S01EB01 - pilocarpine ; Belongs to the class of parasympathomimetics. Used in the treatment of glaucoma and miosis.
N07AX01 - pilocarpine ; Belongs to the class of other parasympathomimetics.
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