Pyrazinamide


Generic Medicine Info
Administration
Should be taken with food.
Contraindications
Hypersensitivity. Hyperuricaemia and/or gouty arthritis, acute porphyria. Severe hepatic impairment.
Special Precautions
Patient w/ DM, history of gout. Mild to moderate hepatic and renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor liver function, serum uric acid, sputum culture; chest x-ray 2-3 mth into treatment and at completion.
Adverse Reactions
Hyperuricaemia, leading to acute gout; anorexia, nausea, vomiting, aggravation of peptic ulcer, arthralgia, malaise, fever, sideroblastic anaemia, thrombocytopenia, dysuria. Rarely, photosensitivity, pellagra, rash.
Potentially Fatal: Hepatotoxicity.
Drug Interactions
Antagonises the effect of uricosuric agents (e.g. probenecid, sulfinpyrazone). May reduce the contraceptive effect of oestrogens. May inactivate oral typhoid vaccine. May increase the serum concentration of ciclosporin. May enhance the hepatotoxic effect of rifampicin.
CIMS Class
ATC Classification
J04AK01 - pyrazinamide ; Belongs to the class of other drugs used in the systemic treatment of tuberculosis.
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