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Profession Email
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Indications/Uses
Depression.
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Dosage/Direction for Use
Adult: PO 4 mg twice daily, then up to 10 mg/day after 3-4 wk if needed. Max: 12 mg/day.
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Administration
May be taken with or without food.
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Special Precautions
Renal and hepatic impairment, benign prostatic hyperplasia, cardiac disorders, epilepsy, bipolar disorders, urinary retention, glaucoma. May impair ability to perform tasks requiring mental alertness, driving or operating machinery. Monitor for signs of clinical worsening eg. suicidal tendency especially during the initial phase of the treatment.
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Adverse Reactions
Insomnia, dizziness, increased sweating, impotence, dry mouth, constipation, urinary hesitancy, dry mouth, postural hypotension, dysuria, paraesthesia, hyponatraemia, tachycardia.
Potentially Fatal: Tachycardia. |
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Drug Interactions
Avoid concomitant admin with antiarrhythmics, antipsychotics, ciclosporin, imidazole and triazole antifungals, TCAs. Concurrent use with CYP3A4 inhibitors may increase plasma levels of reboxetine. Concurrent use with ergot derivatives may increase BP.
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CIMS Class
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ATC Classification
N06AX18 - reboxetine ; Belongs to the class of other antidepressants.
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