Concise Prescribing Info
Listed in Dosage.
Dosage/Direction for Use
Adult: PO Erythema nodosum leprosum (Type 2) 100-300 mg at bedtime, reduce gradually once a satisfactory reponse is achieved. Max: 400 mg/day. Multiple myeloma Initial: 200 mg once daily, increase slowly according to patient tolerance. Max: 800 mg/day.
Should be taken on an empty stomach. Take on an empty stomach at least 1 hr after a meal, w/ a full glass of water.
Pregnancy and lactation.
Special Precautions
All females of childbearing potential must use 2 reliable forms of contraception simultaneously 4 wk before starting therapy, during and 4 wk after therapy is discontinued. Therapy to be stopped immediately if pregnancy occurs. Male: Use of barrier methods of contraception if partner is of child-bearing potential. Do not donate blood or sperm during therapy. Patient should not drive or operate machinery. Discontinue therapy if any skin rash develops. Do not resume therapy if the rash is exfoliative, purpuric, or bullous, or if Stevens-Johnson syndrome or toxic epidermal necrolysis suspected.
Adverse Reactions
Severe and irreversible peripheral neuropathy, constipation, dizziness, orthostatic hypotension, drowsiness, somnolence, bradycardia, increase of viral load in HIV-infected patients, hypersensitivity reaction.
Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis and blood dyscrasias.
Drug Interactions
Thalidomide enhances sedative activity of barbiturates, alcohol, chlorpromazine and reserpine. Avoid use of other drugs that have the potential to cause peripheral neuropathy. Increased risk of thromboembolic events with darbepoetin-alfa and doxorubicin.
ATC Classification
L04AX02 - thalidomide ; Belongs to the class of other immunosuppressants.
Disclaimer: This information is independently developed by CIMS based on thalidomide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by
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