Vancomycin


Generic Medicine Info
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to vancomycin and to other glycopeptide antibiotics (e.g. teicoplanin).
Special Precautions
Patient with inflammatory disorders of the intestinal mucosa, underlying hearing loss or prior deafness, acute anuria, cochlear damage. Renal impairment. Children and elderly. Pregnancy and lactation. Monitoring Parameters Monitor urine, LFT, renal function, and CBC periodically. Monitor serum vancomycin trough concentration 2-3 times weekly; leukocyte count regularly for prolonged use. Perform culture and susceptibility tests; consult local institutional recommendations before treatment initiation due to antibiotic resistance risks.
Adverse Reactions
Significant: Diarrhoea, flushing of the upper body (red man or red neck syndrome), anaphylaxis, infusion reactions (e.g. hypotension, flushing, urticaria), thrombophlebitis, extravasation, nephrotoxicity; neutropenia, bacterial superinfection (prolonged use). Rarely, ototoxicity. Blood and lymphatic system disorders: Rarely, eosinophilia. Gastrointestinal disorders: Abdominal pain, nausea, vomiting. General disorders and administration site conditions: Chills, drug fever, phlebitis, pain. Investigations: Increased serum creatinine and BUN. Musculoskeletal and connective tissue disorders: Muscle spasms of the chest and back muscles. Renal and urinary disorders: Interstitial nephritis, acute tubular necrosis. Respiratory, thoracic and mediastinal disorders: Dyspnoea, stridor. Skin and subcutaneous tissue disorders: Exanthema, mucosal inflammation, rash, pruritus. Vascular disorders: Decrease in blood pressure.
Potentially Fatal: Pseudomembranous colitis, hypersensitivity reactions.
ROUTE(S) : Gastroenteral / PO: B
ROUTE(S) : IV / Parenteral: C
Drug Interactions
Increased risks of ototoxicity and nephrotoxicity with aminoglycoside, amphotericin B, bacitracin, polymyxin B, viomycin, cisplatin, loop diuretics and NSAIDs. May enhance anaesthetic-induced myocardial depression, erythema, histamine-like flushing and anaphylactoid reactions. May prolong and enhance the effects of muscle relaxants (e.g. succinylcholine, vecuronium).
CIMS Class
Other Antibiotics
ATC Classification
S01AA28 - vancomycin
A07AA09 - vancomycin ; Belongs to the class of antibiotics. Used in the treatment of intestinal infections.
J01XA01 - vancomycin ; Belongs to the class of glycopeptide antibacterials. Used in the systemic treatment of infections.
Disclaimer: This information is independently developed by CIMS based on vancomycin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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