Generic Medicine Info
May be taken with or without food.
Patients at risk of coronary artery disease (post-menopausal women, men >40 yr, hypertension, hypercholesterolemia, smoking, obesity, DM, family history of coronary artery disease) unless evaluated. Wolff-Parkinson-White syndrome; arrhythmias associated with accessory cardiac conduction pathways; previous cerebrovascular accident; uncontrolled or severe hypertension; ischaemic heart disease, history of MI, coronary vasospasm, transient ischaemic attack. Basilar or hemiplegic migraine.
Special Precautions
Use only if there is a clear diagnosis of migraine; exclude other potentially serious neurological conditions. Monitor BP closely. May impair ability to drive or operate machinery. Pregnancy and lactation. Child. Moderate to severe hepatic impairment. Prior CV evaluation for patients with risk factors of coronary heart disease; admin of first dose under close supervision and ECG if satisfactory CV assessment in these patients. Periodic CV evaluation for patients with risk factors of coronary arteries on zolmitriptan. Avoid oral disintegrating formulation for patients with phenylketouria. Long term use may cause accumulation of zolmitriptan in melanin rich tissue (e.g. eye).
Adverse Reactions
Dizziness, asthenia, dry mouth, hyperesthesia, paresthesia, drowsiness, nausea, pain or sensations of tingling, heaviness, pressure or tightness in any part of the body including throat/chest; cerebrovascular events; transient increases in blood pressure; hypotension, ischaemic colitis, GI infarction, hypersensitivity reactions, coronary vasospasm.
Potentially Fatal: Cardiac arrhythmias, MI, subarachnoid haemorrhage.
Drug Interactions
Increased risk of serotonin syndrome with SSRI, selective serotonin- and norepinephrine-reuptake inhibitors (SNRI). Increased zolmitriptan concentrations with cimetidine, quinolone antibacterials and drugs that inhibit the cytochrome P450 isoenzyme CYP1A2.
CIMS Class
Antimigraine Preparations
ATC Classification
N02CC03 - zolmitriptan ; Belongs to the class of selective serotonin (5HT1) agonists preparations. Used to relieve migraine.
Disclaimer: This information is independently developed by CIMS based on zolmitriptan from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 CIMS. All rights reserved. Powered by CIMSAsia.com
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