Hyperlipidaemias
Adult: 250 mg bid or tid. Max: 1,200 mg daily.
Indications and Dosage
Oral
Hyperlipidaemias Adult: 250 mg bid or tid. Max: 1,200 mg daily.
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Renal Impairment
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Administration
Should be taken with food. Take w/ or after meals.
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Contraindications
Peptic ulcer. Severe renal impairment (CrCl <30 mL/min).
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Special Precautions
Renal impairment (CrCl 30-60 mL/min).
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Adverse Reactions
Peripheral vasodilatation, resulting in flushing, itching and sensation of heat; rash, erythema, heartburn, epigastric pain, nausea, diarrhoea, headache, myalgia, arthralgia, dry eye, malaise, myositis. Rarely, urticaria, angioedema, bronchospasm.
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MonitoringParameters
Monitor hepatic and renal function. Measure lipid profile before treatment and serum lipids periodically.
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Drug Interactions
Risk of myopathy is increased when nicotinic acid is given concomitantly w/ a statin, as acipimox is structurally related to nicotinic acid, caution should be taken when used w/ such agents.
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Action
Description: Acipimox inhibits the release of fatty acids from adipose tissue and reduces the blood concentrations of VLDL and LDL w/ a subsequent overall reduction in triglyceride and cholesterol levels.
Pharmacokinetics: Absorption: Rapidly and completely absorbed from the GI tract. Time to peak plasma concentration: W/in 2 hr. Excretion: Via urine. Plasma half-life: Approx 2 hr. |
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MIMS Class
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ATC Classification
C10AD06 - acipimox ; Belongs to the class of nicotinic acid and derivatives. Used in the treatment of hyperlipidemia.
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References
Anon. Acipimox. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 10/06/2016. Buckingham R (ed). Acipimox. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/06/2016. Joint Formulary Committee. Acipimox. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/06/2016. Pfizer New Zealand Ltd. Olbetam 250 mg Capsules data sheet 08 January 2014. Medsafe. http://www.medsafe.govt.nz/. Accessed 10/06/2016.
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