Concise Prescribing Info
Contents
Co-amoxiclav (amoxicillin 500 mg, clavulanic acid 125 mg)
Indications/Uses
Upper & lower resp tract, GUT, skin & soft tissue, bone & joint, dental & other infections eg, septic abortion, puerperal & intraabdominal sepsis.
Dosage/Direction for Use
Adult & childn >12 yr Mild to moderate infections 250 mg 3 times daily. Severe infections 500 mg 3 times daily. Childn Usual recommended dose: 25 mg/kg/day 8 hrly in divided doses. Dental infections Adult & childn >12 yr 250 mg 3 times daily for 5 days.
Contraindications
Hypersensitivity to penicillin. History of cholestatic jaundince/hepatic dysfunction. Neonates whose mothers are hypersensitive to penicillin or its derivatives.
Special Precautions
Avoid prolonged use. Severe hepatic impairment, moderate or severe renal impairment. Pregnancy & lactation.
Adverse Reactions
Nausea, vomiting, diarrhoea, indigestion, pseudomembranous colitis; candidiasis; hepatitis, cholestatic jaundice; urticarial & erythematous rashes, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis; nephritis; trancient leucopenia, thrombocytopenia & hemolytic anemia.
Drug Interactions
OCs, anticoagulants.
MIMS Class
ATC Classification
J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Presentation/Packing
Form
Amiclav caplet
Packing/Price
5 × 6's (Rp330,000/boks)
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