Brexel

Brexel

docetaxel

Manufacturer:

Dankos
Concise Prescribing Info
Contents
Docetaxel
Indications/Uses
Breast, ovarian & neck cancer. Non-small cell lung cancer. Hormone refractory prostate cancer. Gastric adenocarcinoma & squamous cell carcinoma of the head.
Dosage/Direction for Use
IV Breast cancer Recommended dose: 100 mg/m2 over 1 hr 3 wkly. 1st-line treatment: 75 mg/m2 in combination w/ doxorubicin 50 mg/m2. Non-small cell lung cancer Failure of prior platinum-based chemotherapy Recommended dose: 75 mg/m2 over 1 hr 3 wkly. Chemotherapy-naive patient Recommended dose: 75 mg/m2 over 1 hr immediately followed by cisplatin 75 mg/m2 over 30-60 min 3 wkly. Ovarian cancer Recommended dose: 100 mg/m2 as 1 hr infusion 3 wkly. Prostate cancer Hormone refractory metastatic prostate cancer Recommended dose: 75 mg/m2 over 1 hr 3 wkly. Prednisone 5 mg orally twice daily administered continuously. Neck cancer, gastric adenocarcinoma & squamous cell carcinoma of the head 75-100 mg/m2 over 1 hr 3 wkly.
Contraindications
Hypersensitivity to docetaxel or to other drugs formulated w/ polysorbate 80. Neutrophil counts <1,500 cells/mm3. Severe liver impairment. Pregnancy & lactation.
Special Precautions
Hypersensitivity reactions. All patients should be premedicated w/ oral corticosteroids for 3 days starting 1 day prior to docetaxel therapy. Monitor for neutropenia, cutaneous reaction, fluid retention, neurosensory symptoms, asthenia & cardiac toxicity. Contraceptive measures must be taken during & for at least 3 mth after therapy. Avoid contact w/ plasticized PVC equipment. Renal & hepatic impairment. Childn <16 yr. Elderly.
Adverse Reactions
Neutropenia, myelosuppression, hypersensitivity, neuropathy, cutaneous & infusion site reactions, alopecia, fluid retention, peripheral neurotoxicity, dysgeusia, dizziness, stomatitis, diarrhea, nausea, vomiting, taste perversion, constipation, abdominal pain, GI bleeding, esophagitis, hypotension, abnormal hepatic function, elevation of liver enzymes, myalgia, arthralgia, resp disorder.
Drug Interactions
Compd that induce, inhibit or are metabolized by CYP450 3A4 eg, cyclosporine, terfenadine, ketoconazole, erythromycin & troleandomycin. Increased clearance w/ doxorubicin. Carboplatin.
ATC Classification
L01CD02 - docetaxel ; Belongs to the class of plant alkaloids and other natural products, taxanes. Used in the treatment of cancer.
Presentation/Packing
Form
Brexel infusion 80 mg/8 mL
Packing/Price
((ready to use)) 1's (Rp1,000,000.00/vial)
Form
Brexel infusion 20 mg/2 mL
Packing/Price
1's (Rp250,000.00/boks)
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