Dequalinium


Generic Medicine Info
Indications and Dosage
Oral
Minor infections of the mouth and throat
Adult: Suck 1 loz (0.25 mg) up to 6 times daily. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).

Vaginal
Bacterial vaginosis
Adult: Insert 1 vaginal tab (10 mg) once daily at bedtime for 6 days. Interrupt treatment during menstruation and resume afterwards.
Contraindications
Vaginal tab: Hypersensitivity. Ulceration of the vaginal epithelium and the vaginal portion of the cervix.
Special Precautions
Avoid the use of vaginal tab within 12 hours before birth. Vaginal tab is not indicated for use prior to menarche. Pregnancy and lactation.
Adverse Reactions
Gastrointestinal disorders: Glossalgia (loz).
General disorders and administration site conditions: Fever (vaginal tab).
Reproductive system and breast disorders: Vaginal discharge or candidiasis, vulvovaginal pruritus or burning sensation (vaginal tab).
Patient Counseling Information
Vaginal tab: Use a sanitary towel or pantyliner following administration. Avoid the use of non-latex condoms and other intravaginal devices for at least 12 hours following the treatment.
Drug Interactions
Anionic substances (e.g. soaps, vaginal wash, detergents, surfactants) may reduce the antimicrobial activity of dequalinium vaginal tab; avoid concomitant use.
Action
Description: Dequalinium is a quaternary ammonium anti-infective agent against gram-positive and gram-negative bacteria, fungi and yeasts. It increases bacterial cell permeability and reduces enzymatic activity, thus causing cell death.
Onset: 30-60 minutes (vaginal tab).
Chemical Structure

Chemical Structure Image
Dequalinium

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 2993, Dequalinium. https://pubchem.ncbi.nlm.nih.gov/compound/Dequalinium. Accessed June 27, 2022.

Storage
Store below 30°C.
MIMS Class
Preparations for Oral Ulceration & Inflammation / Preparations for Vaginal Conditions
ATC Classification
G01AC05 - dequalinium ; Belongs to the class of quinolone derivative antiinfectives. Used in the treatment of gynecological infections.
R02AA02 - dequalinium ; Belongs to the class of antiseptics used in throat preparations.
References
Anon. Dequalinium. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 16/03/2022.

Buckingham R (ed). Dequalinium Chloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/03/2022.

Dequa Lozenges (Dynapharm [M] Sdn. Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 16/03/2022.

Dequadin Lozenges (Sterling Drug [M] Sdn Bhd). MIMS Malaysia. http://www.mims.com/malaysia. Accessed 16/03/2022.

Fluomizin 10 mg Vaginal Tablets (Kora Corporation Ltd). MHRA. https://products.mhra.gov.uk. Accessed 16/03/2022.

Fluomizin Vaginal Tablets (DKSH Malaysia Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 16/03/2022.

Joint Formulary Committe. Dequalinium Chloride. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/03/2022.

Disclaimer: This information is independently developed by MIMS based on Dequalinium from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by MIMS.com
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