Advanced prostate cancer in combination w/ LHRH analogue therapy or surgical castration.
Dosage/Direction for Use
Adult male including the elderly 1 tab once a day. Start at least 3 days prior to LHRH analogue treatment, or at the same time as surgical castration.
May be taken with or without food.
Hypersensitivity. Co-administration of terfenadine, astemizole or cisapride. Females. Childn.
Moderate to severe hepatic impairment. Consider periodic liver function testing due to the possibility of hepatic changes. Discontinue if changes are severe. Co-administration w/ drugs metabolised predominantly by CYP3A4. Closely monitor prothrombin time in patients who are receiving coumarin anticoagulants.
Breast tenderness, gynaecomastia, hot flushes; diarrhoea, nausea, hepatic changes (elevated levels of transaminases, jaundice), asthenia, pruritus.