Gabexal

Gabexal

gabapentin

Manufacturer:

Sandoz

Marketer:

Novartis Indonesia
Concise Prescribing Info
Contents
Gabapentin
Indications/Uses
Adjunctive therapy in patients who cannot be controlled w/ single or combination antiepileptic drugs or w/ intolerance to antiepileptics in therapeutic doses. Simple & complex partial seizures w/ or w/o secondary tonic-clonic seizures. Neuropathic pain in adults ≥18 yr.
Dosage/Direction for Use
Adult Epilepsy or neuropathic pain Day 1: 300 mg once daily in the morning. Day 2: 300 mg twice daily (morning & evening). Day 3: 300 mg 3 times daily (morning, afternoon & evening). Max dose: 2.4 g daily in divided doses. Dose range: 0.9-1.8 g daily. Total daily dose divided in 3 times/day. Max dosing interval: 12 hr. Renal impairment CrCl 60-90 mL/min 400 mg 3 times daily, 30-60 mL/min 300 mg twice daily, 15-30 mL/min 300 mg once daily, <15 mL/min 300 mg every 2nd day. Hemodialysis Initially 300-400 mg. Maintenance dose: 200-300 mg every 4 hr after dialysis.
Administration
May be taken with or without food.
Contraindications
Special Precautions
Patients w/ renal failure, mixed seizures including absence discharge (petit mal). Avoid abrupt w/drawal in epileptic patients. False positive results in dipstick-test Ames N-Mulistix sg. Not to take 12 hr between 2 doses. Pregnancy & lactation. Childn <18 yr.
Adverse Reactions
Somnolence, dizziness, ataxia, fatigue, nystagmus, headache, tremor, diplopia, amblyopia, rhinitis, nausea & vomiting. Wt gain, increased appetite, fever, pharyngitis, dry mouth/throat, dysarthria, dyspepsia, diarrhea, constipation, abdominal pain, back pain, depression, insomnia, peripheral edema, cough, anxiety, mood swings, amnesia, myalgia, confusion, impotence, skin rash, itching, acne, fracture, leucopenia.
Drug Interactions
Reduced bioavailability w/ antacids.
MIMS Class
ATC Classification
N03AX12 - gabapentin ; Belongs to the class of other antiepileptics.
Presentation/Packing
Form
Gabexal cap 100 mg
Packing/Price
3 × 10's (Rp110,550/boks)
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