Garena

Garena

moxifloxacin

Manufacturer:

Fahrenheit
Concise Prescribing Info
Contents
Moxifloxacin
Indications/Uses
Bacterial infections in adult (≥18 yr) eg, acute exacerbations of chronic bronchitis, community-acquired pneumoniae, acute bacterial sinusitis, complicated skin & skin structure infections, intra-abdominal infections, intolerance to alternative agents (penicillin allergy).
Dosage/Direction for Use
400 mg once daily. Duration of administration: Acute exacerbation of chronic bronchitis 5-10 days. Community-acquired pneumoniae 10 days. Acute sinusitis 7 days. Complicated skin & skin structure infections 7-21 days. Complicated intra-abdominal infections 5-14 days.
Contraindications
Hypersensitivity. History of tendon disease/disorder assoc w/ quinolones; congenital or documented acquired QT prolongation; electrolyte disturbances eg, hypokalaemia; bradycardia; heart failure w/ reduced left-ventricular ejection fraction; symptomatic arrythmias. Concurrent use w/ class IA (eg, quinidine, procainamide) & class III antiarrythmics (eg, amiodarone, sotalol). Patient w/ liver function impairment (Child Pugh C); transaminases increase >5 fold ULN; CrCl <30 mL/min/1.73 m2 (serum creatinine >265 μmol/L) or undergoing renal dialysis. Pregnancy & lactation. Patient <18 yr.
Special Precautions
Hypersensitivity reactions. Patient w/ CNS disorder or history of seizure, visual impairment, myasthenia gravis, complicated pelvic disease. Concomitant medication that reduce K & Mg levels may cause Qtc prolongation. Tendon inflammation & rupture w/ corticosteroids. Discontinue treatment & perform ECG for signs of cardiac arrhythmia. Avoid exposure to UV irradiation or extensive sunlight. Liver dysfunction, pseudomembranous colitis, G6PD deficiencies, Stevens-Johnson syndrome, toxic epidermal necrolysis. May impair ability to drive & use machines. Elderly.
Adverse Reactions
Increased γ-glutamyl-transferase.
Drug Interactions
Antacids containing Mg or Al, didanosine, sucralfate & Fe or Zn. Increased Cmax of digoxin w/o affecting AUC or trough levels. Decreased peak plasma conc of glibenclamide. Neuroleptic, antimalarials, azole antimycotics, macrolides, antihistamine.
MIMS Class
Quinolones
ATC Classification
J01MA14 - moxifloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
Presentation/Packing
Form
Garena soln for infusion 1.6 mg/mL
Packing/Price
250 mL x 1's
Form
Garena tab 400 mg
Packing/Price
1 × 10's
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