Gracef

Gracef

ceftriaxone

Manufacturer:

Gracia Pharmindo
Concise Prescribing Info
Contents
Ceftriaxone Na
Indications/Uses
Acute otitis media, lower resp tract infection, uncomplicated gonorrhea, UTI, pelvic inflammatory disease, bacterial septicemia, bone & joint infection, intra-abdominal infection, meningitis. Pre-op infection prophylaxis.
Dosage/Direction for Use
Adult & childn >12 yr 1-2 vial once daily, may be increased to 4 vial once daily for severe infection. Daily doses >4 vials should be given 12 hrly. Childn <12 yr 20-80 mg/kg/day depending on severity of disease, may be given 24 hrly. Childn >50 kg Adult dose. Treatment of meningitis in infant & childn Initially 100 mg/kg once daily. Pre-op infection prophylaxis Adult 1-2 vials as a single dose 30-90 min pre-op.
Contraindications
Hypersensitivity to cephalosporins & penicillins.
Special Precautions
May cause pseudomembranous colitis in patients who suffer diarrhea after being treated by antibacterial agents; bilirubinemia. Pregnancy & lactation. Neonates (especially premature infants).
Adverse Reactions
Systemic: GI discomfort, diarrhea, nausea, vomiting, stomatitis, glossitis; exanthema, allergic dermatitis, pruritus, urticaria, edema, erythema multiforme; eosinophilia, hematoma, thrombocytopenia, leucopenia, granulocytopenia, haemolytic anemia. Local: Inflammatory reactions in blood vessels after IV administration.
Drug Interactions
Antagonistic effect w/ chloramphenicol. False +ve in Coombs' test & galactosemia. Ca-containing soln. Vancomycin, aminoglycosides.
MIMS Class
Cephalosporins
ATC Classification
J01DD04 - ceftriaxone ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Presentation/Packing
Form
Gracef inj 1 g
Packing/Price
1's (Rp160,000/boks)
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