Adult 1-2 times daily. Childn 1 tab is not suitable for childn weighing <31 kg. Max: 6.5 mg/kg/day based on ideal body wt.
Should be taken with food.
Hypersensitivity to 4-aminoquinolone compd. Eye maculopathy. Childn <6 yr (<31 kg).
Eye examination related to the risk of retinopathy before treatment & after 5 yr of treatment, repeated every 12 mth. Stricter eye examinations are recommended at daily doses exceeding the normal dose. Low visual acuity. Impaired renal function. Elderly.
May increase serum levels of digoxin. Reduction of insulin dose or antidiabetic drugs may be needed. May prolong QT interval & increase risk of ventricular arrhythmias w/ drugs that have the potential to induce cardiac arrhythmias eg, metfloquine. Antiepileptic drug activity may be disrupted. May increase side effects w/ methotrexate. Increased levels of cyclosporine.