Adult: For symptomatic treatment: Lower dose therapy: Patients ≤45 kg: 150 mg tid; >45kg: 300 mg tid. After at least 6 mth of low dose therapy, may increase to higher dose if clinical benefit and tolerability are observed. Higher dose therapy: Patients ≤45 kg: 450 mg tid; >45kg: 750 mg tid. Return to lower dose if no additional improvement is observed after 6 mth on high dose therapy.
Cosmetic treatment of wrinkles
Adult: As a 1% cream: Apply a pea-sized amount of cream to clean, dry face and neck once daily for the first wk. If tolerated, may increase to twice daily.