Interpim

Interpim

cefepime

Manufacturer:

Interbat
Concise Prescribing Info
Contents
Cefepime HCl
Indications/Uses
Adult ≥16 yr: Lower resp tract infection (pneumonia & bronchopneumonia), complicated upper & lower UTI, skin & skin structure infections, intra-abdominal infections (peritonitis, biliary tract infection), severe &/or complicated genital infections, septicemia, empiric treatment in febrile neutropenia. Childn 2 mth-16 yr: Severe pneumonia, empiric treatment in febrile neutropenia.
Dosage/Direction for Use
Adult Mild to moderate UTI 500 mg-1 g IM/IV. Mild to moderate infections except UTI 1 g IM/IV. Severe infections 8 g IV. Very severe or life-threatening infections 2 g IV. All doses given 12 hrly. Childn 2 mth-16 yr ≤40 kg Pneumonia 50 mg/kg 12 hrly for 7-10 days. Empiric treatment in febrile neutropenia 50 mg/kg 8 hrly for 7-10 days.
Contraindications
Hypersensitivity to cephalosporins or other β-lactams.
Special Precautions
Hypersensitivity to penicillins. History of GI disturbances especially colitis. Impaired kidney function. Pregnancy & lactation. Infant <2 mth. Elderly.
Adverse Reactions
Rash, pruritus, fever, diarrhea, nausea, vomiting, constipation, abdominal pain, gastric disturbances, chest pain, tachycardia, cough, sore throat, dyspnea, headache, dizziness, vaginitis, peripheral edema, back pain, encephalopathy, seizure, muscle cramp, kidney failure, anaphylactic reactions, transient leucopenia, neutropenia, agranulocytosis, thrombocytopenia, phlebitis & inflammation at inj site, urticaria, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, colitis, kidney dysfunction, toxic nephropathy, aplastic anemia, hemolytic anemia, bleeding, convulsion, impaired liver function including cholestasis, false positive in urine glucose test result.
Drug Interactions
Ampicillin soln, metronidazole, vancomycin, gentamicin, tobramycin, netilmicin sulfate, aminophylline.
MIMS Class
Cephalosporins
ATC Classification
J01DE01 - cefepime ; Belongs to the class of fourth generation cephalosporins. Used in the systemic treatment of infections.
Presentation/Packing
Form
Interpim powd for inj 1 g
Packing/Price
1's (Rp230,000/vial)
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