Per 50/500 mg Sitagliptin 50 mg, metformin HCl 500 mg. Per 50/1,000 mg Sitagliptin 50 mg, metformin HCl 1,000 mg
Indications/Uses
As adjunct to diet & exercise to improve glycemic control in type 2 DM inadequately controlled on metformin or sitagliptin alone, or patients already receiving combination sitagliptin & metformin.
Individualised dosage not exceeding max daily dose of sitagliptin 100 mg & metformin 2 g. Generally given twice daily. Patient inadequately controlled on metformin alone Usual starting dose: Sitagliptin 50 mg twice daily, plus the dose of metformin already being taken. Patient inadequately controlled on sitagliptin alone Usual starting dose: Sitagliptin 50 mg/metformin HCl 500 mg twice daily. Dose may be titrated up to sitagliptin 50 mg/metformin HCl 1,000 mg twice daily. Switching from co-administration of sitagliptin & metformin May be initiated at the dose of sitagliptin & metformin already being taken.
View Janumet overdosage for action to be taken in the event of an overdose.
Administration
Should be taken with food.
Contraindications
Renal disease or renal dysfunction (serum creatinine levels ≥1.5 mg/dL for males & ≥1.4 mg/dL for females or abnormal CrCl) which may also result from conditions eg, CV collapse (shock); acute MI & septicemia. Acute or chronic metabolic acidosis, including diabetic ketoacidosis, w/ or w/o coma. Patients under radiologic studies involving intravascular administration of iodinated contrast materials. Type 1 diabetes.
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