150-600 mg daily in 2 or 3 divided doses.
Neuropathic pain Initially 75 mg twice daily, may be increased to 150 mg twice daily after 3-7 days, & further to a max of 300 mg twice daily after an additional wk if needed.
Epilepsy Initially 75 mg twice daily, may be increased to 150 mg twice daily after 1 wk, & further to a max of 300 mg twice daily after an additional wk if needed.
Generalized anxiety disorder 150-600 mg daily in 2-3 divided doses. Initially 150 mg daily & may be increased to 300 mg daily after 1 wk, then it can be further increased to 450 mg daily on the next following wk. Max dose: 600 mg daily in the additional wk.
Fibromyalgia 300-450 mg daily in 2 divided doses. Initial dose: 75 mg twice daily, may be increased to 150 mg twice daily after 1 wk, then it can be further increased to 225 mg twice daily on the next following wk.
Patient w/ renal impairment CrCl ≥60 mL/min 150 mg daily in 2 divided doses. Max: 600 mg daily.
CrCl 30-60 mL/min 75 mg daily in 1 or 2 divided doses. Max: 300 mg daily.
CrCl 15-30 mL/min 25-50 mg daily in 1 or 2 divided doses. Max: 150 mg daily.
CrCl <15 mL/min 25 mg single dose daily. Max: 75 mg daily.
Supplementary dose following haemodialysis 25 mg single dose. Max: 100 mg.
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