Usual starting dose & maintenance dose: 50 mg once daily. May be increased to 100 mg. Max effect is reached at 3-6 wk after initial therapy. Patient w/ risk of intravascular vol depletion Initially 25 mg once daily.
May be taken with or without food.
Intravascular vol depletion, history of hepatic impairment, bilateral renal artery stenosis or stenosis of the artery to a solitary kidney. Monitor serum K in elderly & in patient w/ renal impairment. Pregnancy & lactation. Childn.