Lyrica

Lyrica

pregabalin

Manufacturer:

Pfizer
Concise Prescribing Info
Contents
Pregabalin
Indications/Uses
Peripheral & central neuropathic pain in adults. As adjunctive therapy in adults w/ partial seizures w/ or w/o secondary generalization. Generalized Anxiety Disorder (GAD) in adults. Reduce pain in the management of fibromyalgia.
Dosage/Direction for Use
150-600 mg/day in 2 or 3 divided doses. Neuropathic pain Initially 75 mg twice daily. May be increased to 150 mg twice daily after 3- to 7-day interval. Max: 300 mg twice daily after an additional wk. Epilepsy Initially 75 mg twice daily. May be increased to 150 mg twice daily after 1 wk. Max: 300 mg twice daily after an additional wk. GAD 150-600 mg/day in 2-3 divided doses. Treatment can be started w/ 150 mg/day. May be increased to 300 mg/day after 1 wk. Following an additional wk, dose may be increased to 450 mg/day. Max dose: 600 mg/day may be achieved after an additional wk. Fibromyalgia Recommended dose: 300-450 mg/day in 2 divided doses. Initially 75 mg twice daily (150 mg/day), may be increased to 150 mg twice daily (300 mg/day) w/in 1 wk. Patients who do not experience sufficient benefit w/ 300 mg/day may be further increased to 225 mg twice daily (450 mg/day). Renal impairment CrCl ≥60 mL/min Initially 150 mg daily in 2 divided doses. Max dose: 600 mg daily, CrCl ≥30-<60 mL/min Initially 75 mg daily as a single or in 2 divided doses. Max dose: 300 mg daily, CrCl ≥15-<30 mL/min Initially 25-50 mg daily as a single or in 2 divided doses. Max dose: 150 mg daily, CrCl <15 mL/min Initially 25 mg daily as single dose. Max dose: 75 mg daily. Supplementary dose following haemodialysis Initially 25 mg/day single dose. Max: 100 mg/day.
Administration
May be taken with or without food.
Contraindications
Special Precautions
Patients w/ rare hereditary problems of galactose intolerance, Lapp-lactase deficiency or glucose-galactose malabsorption. Adjust hypoglycemic medications in some diabetic patients who gain wt on pregabalin treatment. Discontinue immediately if symptoms of angioedema eg, facial, perioral, or upper airway swelling occur. Transient visual blurring & other changes in visual acuity. W/drawal symptoms. Evaluate patients for history of drug misuse & abuse & observe for signs of pregabalin abuse. CHF patients. Concomitant use w/ opioids. Increased CNS adverse events especially somnolence in the treatment of central neuropathic pain due to spinal cord injury. May influence ability to drive or use machines. Renal impairment. Women of childbearing potential must use effective contraception. Pregnancy & lactation. Childn. Elderly.
Adverse Reactions
Dizziness, somnolence; headache. Nasopharyngitis, increased appetite, euphoric mood, confusion, irritability, depression, disorientation, insomnia, decreased libido; ataxia, abnormal coordination, tremor, dysarthria, amnesia, memory impairment, disturbance in attention, paraesthesia, hypoesthesia, sedation, balance disorder, lethargy; blurred vision, diplopia; vertigo; vomiting, constipation, flatulence, abdominal distension, dry mouth; muscle cramp, arthralgia, back pain, pain in limb, cervical spasm; peripheral oedema, oedema, abnormal gait, fall, feeling drunk, feeling abnormal, fatigue; increased wt; nausea, diarrhea.
Drug Interactions
May potentiate effects of ethanol & lorazepam. Additive impairment of cognitive & gross motor function caused by oxycodone w/ pregabalin. Resp failure, coma & death w/ CNS depressant. Lower GI tract function w/ opioid analgesics.
MIMS Class
Anticonvulsants
ATC Classification
N03AX16 - pregabalin ; Belongs to the class of other antiepileptics.
Presentation/Packing
Form
Lyrica cap 150 mg
Packing/Price
14's (Rp417,564/pak)
Form
Lyrica cap 50 mg
Packing/Price
14's (Rp175,247/pak)
Form
Lyrica cap 75 mg
Packing/Price
14's (Rp253,076/pak)
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