Dyspeptic symptom complex associated w/ delayed gastric emptying eg, epigastric sense of fullness, abdominal distension or swelling, epigastric pain or discomfort. Acute symptoms of nausea & vomiting. May be suitable for chemotherapy- or radiotherapy-induced nasuea & vomiting or post-op nausea & vomiting.
Patients w/ current or history of cardiac disease. Increased risk of serious ventricular arrhythmias & sudden cardiac death. Co-administration w/ potent CYP3A4 inhibitors which have not been shown to cause QT interval prolongation eg, indinavir. Monitor closely for signs & symptoms of AR.
Anti-dyspeptic effect may be antagonized by anticholinergic drugs. Reduced relaxant effect of atropine if administered first. Increased plasma levels & QT prolongation w/ CYP3A4 inhibitors. May influence absorption of concomitantly administered drugs eg, SR or EC formulations due to its gastrokinetic effects.
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