Neurosantin

Neurosantin

gabapentin

Manufacturer:

Sanbe

Marketer:

Sanbe
Concise Prescribing Info
Contents
Gabapentin
Indications/Uses
As adjunctive therapy in the treatment of partial seizures w/ & w/o secondary generalization in adults & childn ≥3 yr. Treatment of neuropathic pain in patients ≥18 yr.
Dosage/Direction for Use
Epilepsy Adult & ped >12 yr 900-1,800 mg daily. Day 1: 300 mg once daily. Day 2: 300 mg twice daily. Day 3: 300 mg 3 times daily. Thereafter dose can be increased in 3 equally divided doses to a max of 2,400 mg daily. Ped 3-12 yr Starting dose: 10-15 mg/kg/day in 3 equally divided doses daily to reach effective dose by upward titration over 3 days. Ped ≥5 yr 25-35 mg/kg/day in 3 equally divided doses daily; 3-<5 yr 40 mg/kg/day in 3 equally divided doses daily. Neuropathic pain Titrate to a max dose of 1,800 mg daily. Day 1: 300 mg once daily. Day 2: 300 mg twice daily. Day 3: 300 mg 3 times daily. Thereafter, dose can be increased using increments of 300 mg daily in 3 divided doses to a max of 1,800 mg daily. Hemodialysis patients Initially 300-400 mg daily then 200-300 mg following each 4 hr of hemodialysis.
Administration
May be taken with or without food: Take at least 2 hr after antacids containing Mg or Al.
Contraindications
Hypersensitivity. Patients w/ acute pancreatitis. Not effective against primarily generalized seizures, eg, absences.
Special Precautions
Abrupt w/drawal of anticonvulsants in epileptic patients may precipitate status epilepticus. Not generally considered effective in the treatment of absence seizures. Concomitant treatment w/ morphine may increase gabapentin conc. Carefully observe for signs of CNS depression eg, somnolence. Severe, life-threatening systemic hypersensitivity reactions eg, drug rash w/ eosinopilia & systemic symptoms (DRESS). Discontinue if signs & symptoms of hypersensitivity eg, fever or lymphadenopathy even w/o rash & no alternative etiology can be established. May impair ability to drive a car or operate machinery. Pregnancy & lactation.
Adverse Reactions
Abdominal, back pain, fatigue, fever, headache, viral infection; vasodilation; constipation, dental abnormalities, diarrhea, increased appetite, dry mouth or throat, nausea &/or vomiting, dyspepsia; leucopenia, decreased WBC; peripheral edema, increased wt; fracture, myalgia; amnesia, ataxia, confusion, abnormal coordination, depression, dizziness, dysarthria, emotional lability, insomnia, nervousness, nystagmus, somnolence, abnormal thinking, tremor, twitching; cough, pharyngitis, rhinitis; abrasion, acne, pruritus, rash; amblyopia, diplopia; impotence.
Drug Interactions
Reduced bioavailability w/ antacids containing Al & Mg. Alcohol or centrally acting drugs of abuse may exaggerate CNS side effects (eg, somnolence & ataxia). False positive readings w/ Ames test when added to other anticonvulsant drugs.
MIMS Class
ATC Classification
N03AX12 - gabapentin ; Belongs to the class of other antiepileptics.
Presentation/Packing
Form
Neurosantin cap 300 mg
Packing/Price
5 × 10's (Rp310,000/boks)
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