Generic Medicine Info
Indications and Dosage
Cerebrovascular insufficiency, Dementia, Peripheral circulatory disorders
Adult: 30 mg 1-2 times daily. Dosage recommendations may vary among countries or individual products. Refer to specific product guidelines.
Should be taken on an empty stomach.
Special Precautions
Patient with hyperuricaemia or history of gout. Renal impairment. Pregnancy.
Adverse Reactions
Significant: Hypotension, hyperuricaemia.
Gastrointestinal disorders: Gastric distress, pyrosis, constipation, diarrhoea, vomiting.
General disorders and administration site conditions: Tiredness.
Nervous system disorders: Dizziness, cephalea.
Psychiatric disorders: Insomnia, drowsiness.
Reproductive system and breast disorders: Sexual impotence, decreased libido.
Vascular disorders: Flushing.
Drug Interactions
May potentiate the effect of antihypertensive drugs.
Description: Nicergoline is a semisynthetic ergot derivative that produces arteriolar vasodilatation both by direct vascular mechanism and by changes in tissue metabolism. At the cerebral level, it increases arterial flow and consumption of oxygen and glucose, thus reducing vascular resistance. It also exerts serotonergic and dopaminergic effects, antiplatelet activity, and improves EEG patterns.
Absorption: Rapidly and well-absorbed. Bioavailability: 5%. Time to peak plasma concentration: 1.5-3 hours (nicergoline); 3-5 hours (MDL); 0.5-1 hour (MMDL).
Distribution: Volume of distribution: 224 L. Plasma protein binding: 34.7% (MDL); 14.7% (MMDL).
Metabolism: Metabolised mainly via hydrolysis to 1-methyl-10 alpha-methoxy-9,10-dihydrolysergol (MMDL), then demethylated by CYP2D6 to form the main active metabolite 10-alpha-methoxy-9, 10-dihydrolysergol (MDL).
Excretion: Mainly via urine (82%); faeces (10%). Elimination half-life: 11-20 hours (MDL).
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 34040, Nicergoline. Accessed Nov. 25, 2021.

Store below 30°C. Protect from moisture.
MIMS Class
Peripheral Vasodilators & Cerebral Activators
ATC Classification
C04AE02 - nicergoline ; Belongs to the class of ergot alkaloids. Used as peripheral vasodilators.
Anon. Nicergoline. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 09/11/2021.

Buckingham R (ed). Nicergoline. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 09/11/2021.

Sermion (Pfizer). MIMS Thailand. Accessed 09/11/2021.

Disclaimer: This information is independently developed by MIMS based on Nicergoline from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by
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