Pergoveris

Pergoveris

Manufacturer:

PT. Merck Tbk
Concise Prescribing Info
Contents
Follitropin α 150 IU, lutropin α 75 IU
Indications/Uses
Stimulation of follicular development in women w/ severe LH & FSH deficiency (endogenous serum LH level <1.2 IU/L).
Dosage/Direction for Use
1 vial daily SC in alternating inj site. May increase FSH dose by 37.5-75 IV after 7-14 day. May extend duration of stimulation in any 1 cycle to up to 5 wk. When an optimal response is obtained, a single inj of 5,000-10,000 IU hCG should be administered 24-48 hr after the last Pergoveris inj. Patient is recommended to have coitus on the day of & on the day following hCG administration. Alternately, intrauterine insemination may be performed. 
Contraindications
Hypersensitivity. Hypothalamus & pituitary gland tumours, ovarian enlargement or cyst not due to polycystic ovarian disease, gynaecological haemorrhages of unknown aetiology & ovarian, uterine or mammary carcinoma. Primary ovarian failure, sexual organ malformations & fibroid tumours of the uterus incompatible w/ pregnancy. Pregnancy & lactation.
Special Precautions
Regular monitoring of ovarian response. Patients w/ porphyria or family history of porphyria. DM, hypothyroidism, adrenocortical deficiency, hyperprolactinemia & pituitary or hypothalmic tumours. Possible excessive oestrogen response & multiple follicular development. Ovarian hyperstimulation syndrome (OHSS). Multiple pregnancies, miscarriage or abortion, ectopic pregnancy on patients w/ history of tubal disease, benign & malignant ovarian & other reproductive system neoplasms. Recent or ongoing thromboembolic disease or recognized risk factor for thromboembolic events.
Adverse Reactions
Headache, ovarian cysts, mild to severe inj site reactions. Somnolence, abdominal pain & GI disturbances, mild or moderate OHSS, breast pain, pelvic pain.
ATC Classification
G03GA30 - combinations ; Belongs to the class of gonadotropins. Used as ovulation stimulants.
Presentation/Packing
Form
Pergoveris powd for inj 150 IU/75 IU
Packing/Price
(+ solvent (vial) 1 mL) 1's (Rp1,201,530/vial)
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