Do not touch the tip of the bottle to the eye directly. Patients w/ aphakia or pseudophakia, bronchial asthma, endophthalmitis; closed-angle glaucoma. Iris & eyelid pigmentation or hypertrichosis around the eyes, corneal epithelium disorder may occur. Take at least 5 min intervals when using >1 ophth soln. Remove contact lenses prior to use. Wait for 15 min prior to wearing contact lenses. May impair ability to drive or operate machinery. Pregnancy & lactation. Childn. Elderly.