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Indications and Dosage
Oral
Thiamine deficiency Adult: Up to 300 mg daily. Oral Treatment and prophylaxis of mild chronic thiamine deficiency Adult: 10-25 mg daily in single or divided doses. Parenteral Wernicke-Korsakoff syndrome Adult: Initially, 100 mg by slow IV Inj over 10 min, then 50-100 mg/day IM or IV until the patient can take oral thiamine.
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Administration
Should be taken with food.
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Incompatibility
Parenteral:
Alkaline or neutral solutions and with oxidizing and reducing agents. |
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Special Precautions
Parenteral admin. Increased daily requirements in pregnancy and lactation.
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Adverse Reactions
IV: Warm sensation, tingling, pruritus, pain, urticaria, weakness, sweating, nausea, restlessness, tightness of the throat, angioedema, respiratory distress, cyanosis, pulmonary oedema, GI bleeding, transient vasodilation and hypotension, vascular collapse. IM: Tenderness and induration.
Potentially Fatal: Very rarely, fatal anaphylactic shock. |
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IM/IV/Parenteral/PO: A
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Drug Interactions
May enhance the effect of neuromuscular blocking agents.
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Lab Interference
False-positive results in the phosphotungstate method for uric acid determination and in the urine spot test with Ehrlich's reagent for urobilinogen. High doses of thiamine reportedly interfere with the Schack and Waxler spectrophotometric determination of theophylline serum concentrations.
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Action
Description: Thiamine, a water soluble vitamin, combines with ATP to form thiamine pyrophosphate, an essential coenzyme in carbohydrate metabolism.
Pharmacokinetics: Absorption: Well-absorbed from the GI tract after oral admin and rapidly and completely absorbed following IM administration. Distribution: Widely distributed in most body tissues; enters breastmilk. Excretion: Excess thiamine is excreted in the urine as metabolites and unchanged drug. |
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Storage
Store between 15-30°C.
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MIMS Class
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