Antineoplastic as IV bolus: Adult
Uromitexan as 20% of the antineoplastic dose on a wt for wt basis given IV at 4-hrly intervals, beginning at the same time as the antineoplastic inj at 0, 4 & 8 hr. Childn
Carry out administrations more frequently (eg, 6 times) & at shorter intervals (eg, 3 hr). Antineoplastic as continuous infusion: Uromitexan as 20% of the total antineoplastic dose given by IV inj, followed by 100% of the total antineoplastic dose by IV infusion over 24 hr, then followed by up to 50% by infusion over a further 12 hr.