Xanax

Xanax

alprazolam

Manufacturer:

Pfizer
Concise Prescribing Info
Contents
Alprazolam
Indications/Uses
Anxiety including anxiety neurosis, disorders & symptoms. Combination of anxiety & depression including anxiety associated w/ depression. Panic disorders w/ or w/o agoraphobia.
Dosage/Direction for Use
Individualized dosage. Anxiety Initially 0.75-1.5 mg daily in divided doses. Usual dose range: 0.5-4 mg daily in divided doses. Panic disorders Initially 0.5-1 mg at bedtime or 0.5 mg 3 times daily. Usual dose range: Adjusted to patient's response. Dose increments should not exceed 1 mg at intervals of 3-4 days. Additional doses can be added until a 3 times or 4 times daily schedule is achieved. Max: 10 mg daily. Geriatric patients Initial & usual dose range: 0.5-0.75 mg daily in divided doses. May be gradually increased if needed & tolerated.
Administration
May be taken with or without food: Side effects eg, sleepiness/drowsiness may be reduced if taken immediately after meals.
Contraindications
Hypersensitivity to benzodiazepines & alprazolam. Acute narrow-angle glaucoma.
Special Precautions
Patients w/ panic-related disorders. Episodes of hypomania & mania. Dosage must be gradually tapered to preclude sequelae of rapid w/drawal. Depression w/ psychosis features, bipolar disorders or “endogenous” depression (eg, severely depressed in-patients). Patients who are prone to abuse drugs (eg, alcoholics & drug addicts). Not recommended in patients whose primary diagnosis is schizophrenia. Caution against engaging in hazardous occupations or activities requiring complete mental alertness eg, operating machinery or driving a motor vehicle. Impaired renal or hepatic function. Increased risk of congenital abnormalities when administered to pregnant woman during the 1st trimester. Not recommended for use in pregnancy. Nursing should not be undertaken while using benzodiazepines. Childn <18 yr. Elderly or debilitated patients.
Adverse Reactions
Depression; sedation, somnolence, ataxia, memory impairment, dysarthria, headache, dizziness; dry mouth, constipation; fatigue, irritability. Decreased appetite; confusional state, disorientation, decreased/increased libido, anxiety, insomnia, nervousness; balance disorder/impairment, coordination abnormal, disturbance in attention, hypersomnia, lethargy, tremor; blurred vision; nausea; sexual dysfunction; decreased/increased wt. Dermatitis.
Drug Interactions
Benzodiazepines produce additive CNS depressant effects when co-administered w/ opioids, other psychotropic medications, anticonvulsants, antihistaminics, ethanol & other dugs which produce CNS depression. Co-administration w/ erythromycin. Dose adjustment or discontinuation of alprazolam when co-administered w/ HIV protease inhibitors (eg, ritonavir). Increased digoxin conc especially in elderly (>65 yr). Co-administration w/ ketoconazole, itraconazole, or other azole type antifungals is not recommended. Dose reduction is recommended when co-administered w/ nefazodone, fluvoxamine & cimetidine. Co-administration w/ fluoxetine, propoxyphene, OCs, diltiazem, or macrolide antibiotics eg, troleandomycin.
MIMS Class
Anxiolytics
ATC Classification
N05BA12 - alprazolam ; Belongs to the class of benzodiazepine derivatives anxiolytics. Used in the management of anxiety, agitation or tension.
Presentation/Packing
Form
Xanax caplet 0.25 mg
Packing/Price
10 × 10's (Rp398,165/boks)
Form
Xanax caplet 0.5 mg
Packing/Price
10 × 10's (Rp568,100/boks)
Form
Xanax caplet 1 mg
Packing/Price
10 × 10's (Rp933,299/boks)
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