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Zonegran

Zonegran

zonisamide

Manufacturer:

Eisai
Concise Prescribing Info
Contents
Zonisamide
Indications/Uses
Monotherapy for partial seizures w/ or w/o secondary generalisation in adults w/ newly diagnosed epilepsy. Adjunctive therapy for partial seizures in adults w/ epilepsy.
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Dosage/Direction for Use
Adult Monotherapy Newly diagnosed patients Titration phase: Wk 1 + 2: 100 mg once daily. Wk 3 + 4: 200 mg once daily. Wk 5 + 6: 300 mg once daily. Maintenance dose: 300 mg once daily, may increase at 2-wkly intervals in increments of 100 mg up to a max of 500 mg. Adjunctive therapy Initially 100 mg once daily, may be increased to 200 mg after 2 wk for 2 wk, then may be further increased to 300 & 400 mg for 2 wk.
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Overdosage
View Zonegran overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food: Swallow whole, do not chew/crush.
Contraindications
Hypersensitivity to zonisamide or sulfonamides.
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Warnings
For additional cautionary notes to warn of the potential risk of using the medicine... Click to view Zonegran detailed prescribing information
Special Precautions
Discontinue use in patients who develop unexplained rash (eg, SJS & TEN); predisposing risk factors of kidney stone formation; acute renal failure or a clinically significant sustained increase in the creatinine/BUN conc. Cases of aplastic anemia & agranulocytosis. Monitor closely for evidence of decreased sweating & increased body temp especially in ped patients; signs of suicidal ideation & behaviours. Concomitant use w/ carbonic anhydrase inhibitors & drugs w/ anticholinergic activity; drugs that either induce or inhibit CYP3A4 may alter serum conc of zonisamide. Abrupt w/drawal may precipitate increased seizure frequency or status epilepticus. Assess markers of muscle damage including serum creatine phosphokinase & aldolase levels; pancreatic lipase & amylase levels. May impair ability to drive, operate machinery or perform hazardous task. Hepatic & renal dysfunction. Use of effective contraception is advised in women of child bearing potential. Pregnancy & lactation. Childn <16 yr. Elderly.
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Adverse Reactions
Somnolence, anorexia, dizziness, headache, nausea, agitation/irritability, fatigue &/or ataxia, difficulty concentrating, difficulty w/ memory, mental slowing, vomiting, & wt loss; accidental injury, asthenia; tremor, convulsions, abnormal gait, hyperesthesia, incoordination; pharyngitis, cough increased; pruritus; amblyopia, tinnitus.
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Drug Interactions
CYP3A4 inducers or inhibitors may alter zonisamide serum conc.
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Caution For Usage
For caution against possible variation of physical aspect of medicine... Click to view Zonegran detailed prescribing information
Storage
View Zonegran storage conditions for details to ensure optimal shelf-life.
Description
View Zonegran description for details of the chemical structure and excipients (inactive components).
Action
View Zonegran mechanism of action for pharmacodynamics and pharmacokinetics details.
MIMS Class
Anticonvulsants
ATC Classification
N03AX15 - zonisamide ; Belongs to the class of other antiepileptics.
Presentation/Packing
Form
Zonegran tab 100 mg
Packing/Price
10 × 10's
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