Discontinue use at 1st appearance of skin rash, mucosal lesions or any other sign of hypersensitivity; if abnormal LFTs persist or worsen, clinical signs or symptoms consistent w/ liver disease develop or other manifestations eg, eosinophilia or rash occur. Avoid use in case of varicella infection. Active or previous history of bronchial asthma; cerebrovascular bleeding; serious GI ulceration, bleeding or perforation, ulcerative colitis or Crohn's disease, haematological abnormalities; CHF NYHA I, significant risk factors for CV events eg, HTN, hyperlipidaemia, DM, smoking; SLE, mixed connective tissue disorders. May reversibly inhibit platelet aggregation. Monitor renal & hepatic function, blood counts regularly during long-term use. Avoid concomitant use w/ other NSAIDs eg, COX-2 selective inhibitors. Concomitant use w/ diuretics; systemic corticosteroids, anticoagulants eg, warfarin, SSRIs, antiplatelets eg, aspirin. May affect ability to drive & use machines. Hepatic porphyria. Mild to moderate renal & hepatic impairment. May impair female fertility. Not recommended in women of childbearing potential, during 1st & 2nd trimesters of pregnancy. Avoid use during lactation. Not recommended in childn. Elderly.