Aldurazyme

Aldurazyme

Manufacturer:

Genzyme

Distributor:

DKSH
Concise Prescribing Info
Contents
Laronidase
Indications/Uses
Hurler & Hurler-Scheie forms of mucopolysaccharidosis I & Scheie form w/ moderate to severe symptoms.
Dosage/Direction for Use
Special Precautions
Discontinue use if anaphylactic, other severe hypersensitivity or infusion reactions occur. Acute febrile or resp illness; pre-existing upper airway obstruction; patients susceptible to fluid overload, w/ acute underlying resp illness or compromised cardiac &/or resp function. Pretreatment w/ antihistamine, antipyretics or both 60 min prior to infusion & evaluate airway patency prior to treatment initiation. Concomitant use w/ epinephrine. Pregnancy & lactation. Elderly ≥65 yr.
Adverse Reactions
Infusion reactions, pyrexia, rash. Patients ≥6 yr: Infusion reactions eg, flushing, headache, abdominal pain or discomfort, inj site reaction; back & musculoskeletal pain. Patients ≤6 yr: Otitis media, central venous catheterization requirement; infusion reactions eg, chills, increased BP, tachycardia, decreased O2 saturation, pallor, tremor, resp distress, wheezing, crepitations (pulmonary), pruritus.
MIMS Class
Other Agents Affecting Metabolism
ATC Classification
A16AB05 - laronidase ; Belongs to the class of enzymes. Used in the treatment of alimentary tract and metabolism problems.
Presentation/Packing
Form
Aldurazyme infusion 2.9 mg/5 mL
Packing/Price
1's
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