Avezol

Avezol

fluconazole

Manufacturer:

Avex

Distributor:

Apex
Concise Prescribing Info
Contents
Fluconazole
Indications/Uses
Acute or recurrent genital & vag candidiasis, candidal balanitis, dermatomycosis including tinea pedis, tinea corporis, tinea cruris, tinea versicolor, dermal candida infections.
Dosage/Direction for Use
Adult Vag candidiasis/candidal balanitis 150 mg single dose. Dermal infections including tinea pedis, corporis, cruris & candida infections 150 mg once wkly for 2-4 wk. Tinea pedis Up to 6 wk. Tinea versicolor 300 mg once wkly for 2 wk, 3rd wkly dose: 300 mg may be needed or 300-400 mg single dose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to fluconazole or other azoles. Co-administration w/ terfenadine or cisapride.
Special Precautions
Hypersensitivity. Discontinue use if signs or symptoms of liver disease develops. AIDS patients, QT prolongation, cardiomyopathy, sinus bradycardia, existing symptomatic arrhythmias, electrolyte disturbances. Concomitant medication not metabolized by CY34A but prolonging QT interval. Women of childbearing potential should use effective contraception. Avoid use during pregnancy. Not recommended during lactation. Childn <16 yr.
Adverse Reactions
Headache; rash; abdominal pain, diarrhoea, flatulence, nausea.
Drug Interactions
Decreased AUC & shorter t½ w/ rifampicin. Increased plasma conc w/ hydrochlorothiazide. Increased prothrombin time w/ warfarin. Increased midazolam, cyclosporin conc. Prolonged serum t½ of sulphonylureas. Increased phenytoin, terfenadine, rifabutin, tacrolimus serum plasma levels. Increased AUC of ethinyloestradiol, levonorgestrel, zidovudine. Decreased theophylline mean plasma clearance. Cardiac events eg, Torsade de pointes w/ cisapride. Elevated serum levels of CYP450-metabolised drugs.
MIMS Class
Antifungals
ATC Classification
D01AC15 - fluconazole ; Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection.
Presentation/Packing
Form
Avezol cap 150 mg
Packing/Price
1's
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