Discontinue use if serious reactions or hypersensitivity occurs. Risk of metabolic acidosis. Patients w/ compromised corneas eg, w/ DM or corneal dystrophies; low endothelial cell count. Avoid contact w/ soft contact lenses. Remove contact lenses prior to application & wait at least 15 min before reinsertion. Acid-base disturbances w/ oral carbonic anhydrase inhibitors. Renal impairment.