Discontinue use if serious reactions or hypersensitivity occur. Risk of metabolic acidosis. Patients w/ compromised corneas eg, w/ DM or corneal dystrophies; low endothelial cell count. May cause eye irritation due to benzalkonium Cl. Remove contact lens prior to application & wait at least 15 min before reinsertion. Not recommended to use w/ another carbonic anhydrase inhibitors. May affect ability to drive & use machines. Not recommended in hepatic & severe renal impairment. Not recommended during pregnancy. Lactation. Not recommended in childn <18 yr.