Active upper GI problems (eg, Barrett's esophagus, dysphagia, other esophageal diseases, gastritis, duodenitis or ulcers). Discontinue use in case dysphagia, odynophagia, retrosternal pain or new or worsening heartburn occur. Osteonecrosis of the jaw; dental surgery. Correct hypocalcemia & other bone & mineral metabolism disturbances prior to treatment. Concomitant use w/ NSAIDs. Severe renal impairment. Not to be used during pregnancy & lactation. Childn <18 yr.