& AUC w/ strong CYP3A4 inhibitors eg, ketoconazole; moderate CYP3A4 inhibitors eg, diltiazem, amprenavir, aprepitant, erythromycin, fluconazole; cyclosporine. Decreased Cmax
& AUC w/ CYP3A4 inducers eg, rifampicin. Decreased exposure w/ other CYP3A4 inducers eg, phenytoin, carbamazepine, phenobarb. Delayed & decreased exposure w/ morphine. Increased Cmax
& AUC of simvastatin, atorvastatin, digoxin. Increased exposure to CYP3A4 substrates w/ narrow therapeutic index eg, cisapride, ergot alkaloids. Increased risk of bleeding w/ SSRIs eg, paroxetine, sertraline, citalopram. Heparin, enoxaparin, desmopressin; P-gp inhibitors.