Hypersensitivity. Discontinue use if neutropenic fever or absolute neutrophil count <1,000/mm3
occurs. Cholinergic symptoms; hematology toxicities. Not to be used in patients w/ severe bone marrow failure. Patients w/ reduced UGT1A1 activity; late diarrhea; chronic inflammatory bowel disease &/or bowel obstruction; nausea & vomiting; gastric cancer. Symptomatic evidence of orthostatic hypotension in patients w/ dehydration. Preexisting lung disease, use of pneumotoxic drugs, radiation therapy & colony-stimulating factors. Extravasation; extensive prior irradiation; poor performance status. Avoid use w/ live vaccine. Hereditary fructose intolerance. May affect ability to drive & use machines. Hepatic insufficiency. Renal dysfunction. Not recommended for dialysis patients. Women of childbearing potential. Pregnancy. Not to be used during lactation. Childn. Elderly ≥65 yr.