Chlordiazepoxide


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Anxiety 30 mg/day in divided doses, up to 100 mg/day. Muscle spasms 10-30 mg/day in divided doses. Alcohol withdrawal symptoms 25-100 mg/day. Max: 300 mg/day. Insomnia 10-30 mg at bedtime. Duration of treatment: Max 4 weeks including dose tapering of 2 weeks. IV/IM Severe anxiety Initial: 50-100 mg, then 25-50 mg 3-4 times/day.
Dosage Details
Oral
Insomnia
Adult: 10-30 mg at bedtime. Duration of treatment: Max 4 weeks including dose tapering of 2 weeks.
Elderly: and debilitated patients: Dose reduction may be needed.

Oral
Muscle spasms
Adult: 10-30 mg daily in divided doses.
Elderly: and debilitated patients: Dose reduction may be needed.

Oral
Anxiety
Adult: 30 mg daily in divided doses, up to 100 mg daily in severe conditions.
Elderly: and debilitated patients: Dose reduction may be needed.

Oral
Acute symptoms of alcohol withdrawal
Adult: 25-100 mg daily repeated as necessary. Max dose: 300 mg daily.
Elderly: and debilitated patients: Dose reduction may be needed.

Parenteral
Acute anxiety
Adult: Initially, 50-100 mg followed by 25-50 mg 3-4 times daily if necessary. May be given via deep IM or slow IV inj.
Elderly: and debilitated patients: Dose reduction may be needed.
Administration
May be taken with or without food.
Contraindications
Acute pulmonary insufficiency, resp depression, patients with marked neuromuscular resp weakness; hypersensitivity to benzodiazepines; chronic psychosis; porphyria; pregnancy and lactation.
Special Precautions
Alcohol; sedation, dependence. Elderly and debilitated patients. Liver or kidney dysfunction. Avoid prolonged usage.
Adverse Reactions
Physical and psychological dependence; withdrawal syndrome; impairs psychomotor performance, aggression (in predisposed individuals esp in combination with alcohol); sedation; blood dyscrasias, jaundice, hepatic dysfunction.
Potentially Fatal: May rarely cause hypoplastic or haemolytic anaemia.
Drug Interactions
Cimetidine increases serum conc of chlordiazepoxide. Potentiates action of major neuroleptics.
Potentially Fatal: Alcohol potentiates CNS-depressant effect of chlordiazepoxide.
Food Interaction
Alcohol: additive CNS effects, grape juice may increase serum levels and toxicity
Action
Description: Chlordiazepoxide enhances activity of the inhibitory transmitter GABA in different parts of CNS by increasing neuronal-membrane permeability to chloride ions resulting to hyperpolarisation and stabilisation. It has some muscle relaxant and anticonvulsant activity.
Pharmacokinetics:
Absorption: Almost complete (oral); peak plasma concentrations after 1-2 hrs.
Distribution: Crosses the placenta, diffuses into CSF, enters breast milk. Protein-binding: 96%
Metabolism: Hepatic; converted to desmethyldiazepam.
Excretion: Urine (as unchanged drug and metabolites; faeces (conjugated metabolites); 5-30 hrs (elimination half-life).
Storage
Store at 25°C.
Disclaimer: This information is independently developed by MIMS based on Chlordiazepoxide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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