Concise Prescribing Info
Infections of the resp tract, middle ear, paranasal sinuses, eyes, kidneys, urinary tract, GI or biliary tract, skin & soft tissues, bones & joints. Genital infections including adnexitis, gonorrhoea, prostatis; sepsis, peritonitis. Prophylaxis & selective intestinal decontamination in immunocompromised patients.
Dosage/Direction for Use
Resp tract infection 250-500 mg bd. Acute, uncomplicated UTI 125 mg bd or 250 mg once-bd. Pre-menopausal cystitis & acute, uncomplicated gonorrhoea 250 mg as single dose. Complicated UTI 250-500 mg bd. Extragenital gonorrhoea 125 mg bd. Diarrhea 500 mg once-bd. Other infections 500 mg bd. Particularly severe, life-threatening Strep pneumonia, recurrent infections in cystic fibrosis, bone & joint infections, septicaemia, peritonitis, especially when Pseudomonas, Staph or Strep is present 750 mg bd. Duration: Kidney, urinary tract & abdominal cavity infections Up to 7 days. Osteomyelitis Max: 2 mth. Other infections 7-14 days. Strep or Chlamydia infections Min: 10 days. CrCl 31-60 mL/min/1.73 m2 Max daily dose: 1,000 mg, CrCl ≤30 mL/min/1.73 m2 Max daily dose: 500 mg.
May be taken with or without food: May be taken w/ meals to minimise GI discomfort. Swallow whole, do not chew/crush. Do not take w/ dairy products.
Hypersensitivity to ciprofloxacin or quinolones. Pregnancy & lactation. Childn & adolescents 5-17 yr (except association w/ cystic fibrosis).
Special Precautions
Discontinue use at 1st sign of pain or inflammation. Epilepsy, CNS disorders. G6PD deficiency, history of myasthenia gravis, crystalluria. Avoid prolonged exposure to sunlight or UV radiation. May affect ability to drive or operate machinery. Hepatic & renal impairment. Not recommended during pregnancy & lactation. Elderly.
Adverse Reactions
Diarrhoea, nausea, skin rashes. Exacerbation of myasthenia gravis. 
Drug Interactions
Increased serum theophylline conc. Provoked convulsion w/ NSAIDs (except acetylsalicylic acid). Transient rise in serum creatinine conc w/ cyclosporin. Intensified action of warfarin, glibenclamide. Increased serum conc w/ probenecid. Increased plasma levels & associated toxic reactions of methotrexate. Reduced absorption w/ Fe, sucralfate or Mg-, Al- or Ca-containing antacids & highly buffered drugs (eg, didanosine tab). Accelerated absorption by metoclopramide.
MIMS Class
ATC Classification
J01MA02 - ciprofloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
Ciprox film-coated tab 250 mg
10 × 10's
Ciprox film-coated tab 500 mg
10 × 10's
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