Gastric cancer & GEJ adenocarcinoma
8 mg/kg every 2 wk as single agent or in combination w/ paclitaxel: 8 mg/kg on days 1 & 15 of 28-day cycle, prior to paclitaxel 80 mg/m2
IV infusion over approx 60 min on days 1, 8 & 15 of 28-day cycle. Colorectal cancer
8 mg/kg IV infusion every 2 wk prior to FOLFIRI administration. NSCLC
10 mg/kg on day 1 of 21-day cycle, prior to docetaxel 75 mg/m2
IV infusion over approx 60 min on day 1 of 21-day cycle. East Asian patient
Reduce docetaxel to 60 mg/m2
on day 1 of 21-day cycle.