Discontinue use if severe cutaneous lupus erythematosus occurs. Gastric malignancy. Increased risk of Clostridium difficile
-associated diarrhea; osteoporosis-related hip, wrist or spine fractures. Severe hypomagnesaemia; subacute cutaneous lupus erythematosus. Vit B12
malabsorption due to hypo- or achlorhydria. Ensure adequate intake of vit D & Ca. Long-term & high-dose use. Discontinue use at least 5 days prior to chromogranin A measurements. Concomitant use w/ high-dose MTX; digoxin or drugs causing hypomagnesemia eg, diuretics. Severe hepatic impairment. Pregnancy & lactation. Childn <12 yr.