Diovan

Diovan

valsartan

Manufacturer:

Novartis

Distributor:

DKSH
Concise Prescribing Info
Contents
Valsartan
Indications/Uses
Dosage/Direction for Use
HTN Adult 80 or 160 mg once daily, may be increased to 320 mg once daily or another antihypertensive may be added. Heart failure Initially 40 mg bd, up-titrated to 80 & 160 mg bd as tolerated. Max: 320 mg daily in divided dose. Post MI Initially 20 mg bd, up-titrated to max: 160 mg bd as tolerated.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Concomitant use w/ aliskiren in diabetic type 2 patients. Pregnancy.
Special Precautions
Discontinue immediately & not to be re-administered in patients w/ history of or angioedema. Risk of hypotension in Na &/or vol-depleted patients. Heart failure or post MI. Triple combination of ACE inhibitor, β-blocker & Diovan. Concomitant use w/ ACE inhibitors. Avoid concomitant use w/ aliskiren in patients w/ severe renal impairment. Renal artery stenosis, severe renal impairment (CrCl <10 mL/min); biliary cirrhosis or obstruction. Women of childbearing potential. Lactation. Not recommended in childn.
Adverse Reactions
Dizziness, postural dizziness, hypotension, orthostatic hypotension, renal failure & impairment.
Drug Interactions
Increased incidence of hypotension, hyperkalemia & changes in renal function w/ other drugs blocking RAS eg, ACE inhibitors or aliskiren. Increased serum K levels w/ K-sparing diuretics or K supplements. Decreased antihypertensive effects w/ NSAIDs including COX-2 inhibitors. Increased systemic exposure to valsartan w/ uptake transporter inhibitors (rifampin, ciclosporin) or efflux transporter (ritonavir). Increased lithium conc & toxicity.
MIMS Class
Angiotensin II Antagonists
ATC Classification
C09CA03 - valsartan ; Belongs to the class of angiotensin II receptor blockers (ARBs). Used in the treatment of cardiovascular disease.
Presentation/Packing
Form
Diovan FC tab 160 mg
Packing/Price
14's;28's;7's
Form
Diovan FC tab 80 mg
Packing/Price
14's;28's;7's
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