Hypersensitivity to sulfonamides. Discontinue use at 1st appearance of skin rash, mucosal lesions or any other sign of hypersensitivity. Serious skin reactions eg, erythema multiforme, Stevens-Johnson syndrome, hypersensitivity reactions, drug reaction w/ eosinophilia & systemic symptoms syndrome. Increased risk of CV & thromboembolic adverse events; history of active GI disease eg, ulceration, bleeding or inflammatory conditions; severe hypotension; HTN. Patients w/ compromised cardiac function, preexisting edema or other conditions predisposed to or worsened by fluid retention, or at risk of hypovolemia. Ensure adequate hydration. Avoid use w/ non-specific NSAIDs. Concomitant use w/ fluconazole, aspirin, corticosteroids, SSRIs, other antiplatelets & NSAIDs, oral anticoagulants, diuretics; alcohol. Not recommended in severe hepatic impairment. Advanced renal disease; severe renal impairment (CrCl <30 mL/min). Moderate hepatic impairment (Child-Pugh class B). Not recommended in women of childbearing potential. Not to be given during 1st & 2nd trimester of pregnancy. Lactation. Childn <18 yr. Elderly.