Infusion-related reactions including anaphylactic reactions; history of allergy to red meat or tick bites or +ve IgE Ab test results. Discontinue use if interstitial lung disease (ILD) is diagnosed. Temporary interruption if severe skin reactions occur. Not be used for colorectal cancer patients whose tumours have RAS mutations or unknown status. Patients w/ reduced performance status, preexisting cardiopulmonary diseases & haematological disorders; neutropenia & related infectious complications; CV status; history of keratitis, ulcerative keratitis or severe dry eye. Patients w/ confounding or contributing factors eg, concomitant chemotherapy associated w/ ILD & preexisting pulmonary diseases. Determine serum electrolyte levels prior to & periodically thereafter. Concomitant use w/ cardiotoxic compd eg, fluoropyrimidines; combination w/ radiation therapy in colorectal cancer. Contact lens users. May affect ability to drive & use machines. Hepatic & renal impairment. Pregnancy. Not recommended during lactation. Childn <18 yr. Elderly ≥75 yr.