Adult: In combination w/ 1 or 2 anti-TB agents: 15-20 mg/kg daily as single dose or in divided doses. Usually given at an initial dose of 250 mg daily for 1-2 days, increased to 250 mg bid for 1-2 days, then gradually increased to highest tolerated dose. Max: 1 g daily in 3-4 divided doses. Child: 10-20 mg/kg daily in 2-3 divided doses, or alternatively, 15 mg/kg daily as a single dose. Max: 1 g daily.
Should be taken with food. Take at mealtimes.
Hypersensitivity to ethionamide. Severe hepatic impairment.
Patient w/ depression or other psychiatric illness, DM, porphyria, thyroid dysfunction. Hepatic or renal impairment. Pregnancy and lactation.
Monitor serum ALT and AST at baseline and mthly; blood glucose and TSH periodically. Perform ophthalmologic exams prior to and during therapy. Evaluate CNS changes, ocular changes, and neuritis during therapy.
May potentiate AR of other anti-TB drugs. Additive CNS effect w/ isoniazid and cycloserine. May cause seizures w/ cycloserine.
May cause psychotic reaction w/ excessive alcohol ingestion.
Description: Ethionamide’s exact mechanism of action has not been fully elucidated, however, the drug appears to inhibit peptide synthesis. It may be bacteriostatic or bactericidal in action, depending on the concentration of drug attained at the site of infection and susceptibility of organism. Pharmacokinetics: Absorption: Readily absorbed from the GI tract. Time to peak serum concentration: Approx 1 hr. Distribution: Widely distributed throughout body tissues and fluids. Crosses placenta and CSF. Volume of distribution: 93.5 L. Plasma protein binding: 30%. Metabolism: Extensively metabolised in the liver to the active metabolite sulfoxide and some inactive metabolites. Excretion: Via urine (<1% as unchanged drug). Elimination half-life: Approx 2 hr.
J04AD03 - ethionamide ; Belongs to the class of thiocarbamide derivatives. Used in the systemic treatment of tuberculosis.
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