Zuellig Pharma
Concise Prescribing Info
Nadroparin Ca
Prophylaxis of thromboembolic disease in patients undergoing general surgery.
Dosage/Direction for Use
Adult 0.3 mL SC inj 2-4 hr pre-op, then once daily on subsequent days. Continue for at least 7 days & throughout risk period until patient is ambulant.
Hypersensitivity. History of thrombocytopenia. Active bleeding or increased risk of haemorrhage in relation w/ haemostasis disorders except for disseminated intravascular coagulation not induced by heparin; organic lesion likely to bleed eg, active peptic ulceration; haemorrhagic CVA; acute infectious endocarditis. Severe renal impairment (CrCl <30 mL/min) in patients receiving treatment for thromboembolic disorders, unstable angina & non-Q wave MI.
Special Precautions
Not to be used interchangeably w/ other LMWH during ongoing treatment. Heparin-induced thrombocytopenia. Increased risk of bleeding eg, severe arterial HTN, history of peptic ulceration or other organic lesion likely to bleed, vascular chorioretinal disorder; post-op brain, spinal cord or eye surgery; spinal/epidural anaesth/spinal lumbar puncture; cutaneous necrosis. Patients w/ raised plasma K or at risk of increased plasma K levels eg, patients w/ DM, pre-existing metabolic acidosis. Frequently monitor signs & symptoms of neurological impairment. Monitor platelet counts throughout course of treatment. May cause severe allergic reaction due to latex. Concomitant use w/ drugs causing hyperkalemia eg, ACE inhibitors, NSAIDs; platelet inhibitors, other anticoagulants; aspirin, other salicylates. Renal impairment; chronic renal failure. Hepatic impairment. Pregnancy. Not to be used during lactation. Elderly.
Adverse Reactions
Haemorrhagic manifestations at various sites; inj site haematoma. Transient increased transaminases; inj site reaction.
Drug Interactions
Oral anticoagulants, systemic glucocorticosteroids, dextrans.
MIMS Class
Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)
ATC Classification
B01AB06 - nadroparin ; Belongs to the class of heparin group. Used in the treatment of thrombosis.
Fraxiparine soln for inj 2,850 IU AXa
0.3 mL x 10 × 1's
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