Glucosamine


Concise Prescribing Info
Indications/Uses
Osteoarthritis of the knee.
Dosage/Direction for Use
Adult : PO Monotherapy or adjunctive treatment for the symptomatic relief of mild to moderate cases: As glucosamine hydrochloride tab/effervescent tab/cap: Usual dose: 1,250 mg once daily, as a single dose or in 2 divided doses. As glucosamine sulfate tab/powder for oral solution: Usual dose: 1,500 mg once daily, as a single dose or in 2-3 divided doses. Re-evaluate treatment if relief of symptoms is not achieved after 2-3 months.
Dosage Details
Oral
Osteoarthritis of the knee
Adult: Monotherapy or adjunctive treatment for the symptomatic relief of mild to moderate cases: As glucosamine hydrochloride tab/effervescent tab/cap: Usual dose: 1,250 mg once daily, as a single dose or in 2 divided doses. As glucosamine sulfate tab/powder for oral solution: Usual dose: 1,500 mg once daily, as a single dose or in 2-3 divided doses. Re-evaluate treatment if relief of symptoms is not achieved after 2-3 months.
Administration
Should be taken with food. Preferably taken at meals.
Reconstitution
Effervescent tab: Dissolve in at least 100 mL of water. Powder for oral solution: Dissolve in at least 250 mL of water.
Contraindications
Hypersensitivity to glucosamine and shellfish. Children.
Special Precautions
Patient with impaired glucose tolerance, diabetes mellitus, asthma; known risk factors for CV disease. Rule out the presence of other joint diseases. Not indicated for the treatment of acute painful symptoms. Renal and hepatic impairment. Pregnancy and lactation.
Adverse Reactions
Significant: Asthma exacerbation, hypercholesterolaemia, worsened blood glucose control.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, constipation, abdominal pain, heartburn, flatulence, dyspepsia.
General disorders and administration site conditions: Fatigue, peripheral oedema.
Hepatobiliary disorders: Jaundice.
Investigations: Elevated hepatic enzymes.
Nervous system disorders: Headache, dizziness, drowsiness.
Skin and subcutaneous tissue disorders: Rash, pruritus, erythema, urticaria.
Vascular disorders: Flushing.
Patient Counseling Information
This drug may cause dizziness or drowsiness, if affected, do not drive or operate machinery.
MonitoringParameters
Monitor blood glucose levels prior to and periodically thereafter (in patients with impaired glucose tolerance); cholesterol levels (in at risk for CV disease).
Overdosage
Symptoms: Headache, vertigo, dizziness, disorientation, arthralgia, nausea, vomiting, diarrhoea, and constipation. Management: Supportive treatment.
Drug Interactions
May increase the anticoagulant effects of warfarin and acenocoumarol. May increase the absorption and serum levels of tetracyclines.
Action
Description: Glucosamine is a natural substance found in mucoproteins, chitin, and mucopolysaccharides. It stimulates the synthesis of glycosaminoglycans which are responsible for the formation of cartilage in the body. It may be used as a health supplement in the management of musculoskeletal and joint disorders for its supposed chondroprotective activity.
Pharmacokinetics:
Distribution: Volume of distribution: Approx 2.5-5 L.
Metabolism: Extensively metabolised in the liver.
Excretion: Via urine.
Chemical Structure

Chemical Structure Image
Glucosamine

Source: National Center for Biotechnology Information. PubChem Database. D-Glucosamine, CID=439213, https://pubchem.ncbi.nlm.nih.gov/compound/D-Glucosamine (accessed on Jan. 22, 2020)

Storage
Store below 30°C. Protect from light and moisture.
ATC Classification
M01AX05 - glucosamine ; Belongs to the class of other non-steroidal antiinflammatory and antirheumatic products.
References
Alateris 625 mg Tablets (Laboratoires Expanscience). MHRA. https://products.mhra.gov.uk/. Accessed 08/05/2020.

Anon. Glucosamine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 08/05/2020.

Arthriex 750 mg Film-Coated Tablets (TSI Health Sciences [Europe] Ltd). MHRA. https://products.mhra.gov.uk/. Accessed 08/05/2020.

Buckingham R (ed). Glucosamine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/05/2020.

Dolenio 500 mg Film-Coated Tablets (Blue Bio Pharmaceuticals Ltd). MHRA. https://products.mhra.gov.uk/. Accessed 08/05/2020.

Dyna-RH Capsule (Dynapharm [M] Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my/. Accessed 19/05/2020.

Gluco-S 1500 Powder for Oral Solution (MD Pharmaceuticals Pte Ltd). MIMS Singapore. http://www.mims.com/singapore. Accessed 08/05/2020.

Glucosamine 1,250 mg Effervescent Tablets (Medley Pharma Limited). MHRA. https://products.mhra.gov.uk/. Accessed 19/05/2020.

Glusartel 1,500 mg Powder for Oral Solution (Mylan Products Ltd.). MHRA. https://products.mhra.gov.uk/. Accessed 08/05/2020.

Joint Formulary Committee. Glucosamine. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/05/2020.

Yointy 625 mg Hard Capsules (Bioiberica S.A.U.). MHRA. https://products.mhra.gov.uk/. Accessed 08/05/2020.

Disclaimer: This information is independently developed by MIMS based on Glucosamine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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