Zuellig Pharma
Concise Prescribing Info
Carboprost tromethamine
Abortion between 13th & 20th wk of gestation & in the following conditions related to 2nd trimester abortion: Failure of fetus expulsion by another method, premature membrane rupture in intrauterine methods w/ loss of drug & insufficient or absent uterine activity, requirement of repeat intrauterine drug instillation for fetus expulsion, inadvertent or spontaneous membrane rupture in the presence of previable fetus & absence of adequate activity for expulsion. Postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management.
Dosage/Direction for Use
Abortion Initially 250 mcg by deep IM inj then subsequently at 1½-3½ hr intervals depending on uterine response. Total dose: Not to exceed 12 mg; max duration: 2 days. Refractory postpartum uterine bleeding Initially 250 mcg by deep IM inj. Total dose: Not to exceed 2 mg (8 doses).
Hypersensitivity. Acute pelvic inflammatory disease. Active cardiac, pulmonary, renal or hepatic disease.
Special Precautions
Not to be used if fetus in utero has reached viability stege. Not to be considered as feticidal agent. History of asthma, hypotension or HTN, CV disease, anemia, jaundice, diabetes, epilepsy. Patients w/ scarred uteri; spontaneous/incomplete abortion; postpartum hemorrhage; chorioamnionitis. Not recommended in concomitant use w/ oxytocic agents. Renal or hepatic disease. Fatal Gasping Syndrome in premature infants. Pregnancy & lactation. Ped patients.
Adverse Reactions
Vomiting, diarrhea, nausea, flushing, chills, cough, headache, endometritis, hiccough, dysmenorrhea-like pain, paresthesia, backache; muscular, eye, inj site, epigastric & chest pain; breast tenderness, drowsiness, dystonia, asthma, tinnitus, vertigo, vasovagal syndrome, mouth dryness, hyperventilation, resp distress, hematemesis, taste alterations, UTI, septic shock, torticollis, lethargy, HTN, tachycardia, pulmonary edema, endometritis from IUCD, nervousness, nosebleed, sleep disorders, dyspnea, chest tightness, wheezing, posterior cervical perforation, weakness, diaphoresis, dizziness, blurred vision, excessive thirst, twitching eyelids, gagging, retching, dry throat, choking sensation, thyroid storm, syncope, palpitations, rash, upper resp infection, leg cramps, perforated uterus, anxiety, retained placental fragment, shortness of breath, fullness of throat, uterine sacculation, faintness, lightheadedness, uterine rupture.
Drug Interactions
Augmented activity of oxytocic agents.
MIMS Class
Drugs Acting on the Uterus
ATC Classification
G02AD04 - carboprost ; Belongs to the class of prostaglandins. Used to induce abortion or augment labour and to minimize blood loss from the placental site.
Hemabate inj 250 mcg/mL
10 × 1's;1's
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