Hydroquinone


Concise Prescribing Info
Indications/Uses
Hyperpigmentated skin conditions.
Dosage/Direction for Use
Adult : Topical As 2-4% preparation: Apply bid.
Dosage Details
Topical/Cutaneous
Hyperpigmentated skin conditions
Adult: As 2-4% preparation: Apply and rub in a thin layer to affected area bid, in the morning and evening. Discontinue if there is no improvement after 2 mth.
Incompatibility
Incompatible w/ alkalis, ferric salts and oxidizing agents.
Contraindications
Sunburn or depilatory usage.
Special Precautions
Pregnancy and lactation.
Adverse Reactions
Transient erythema, mild burning sensations, irritation, stinging, allergic dermatitis; dryness and fissuring of paranasal and infraorbital areas; ochronosis and colloid milium (chronic use).
Patient Counseling Information
Avoid unnecessary exposure to sunlight.
MonitoringParameters
Test for skin sensitivity prior to use.
Action
Description: Hydroquinone is a topical depigmentating agent that produces a reversible depigmentation of the skin by inhibiting enzymatic oxidation of tyrosine to 3,4-dihydroxyphenylalanine and suppressing melanocyte metabolic processes.
Chemical Structure

Chemical Structure Image
Hydroquinone

Source: National Center for Biotechnology Information. PubChem Database. Hydroquinone, CID=785, https://pubchem.ncbi.nlm.nih.gov/compound/Hydroquinone (accessed on Jan. 23, 2020)

Storage
Store between 20-25°C. Protect from light.
ATC Classification
D11AX11 - hydroquinone ; Belongs to the class of other dermatologicals.
References
Anon. Hydroquinone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/07/2016.

Buckingham R (ed). Hydroquinone. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/07/2016.

Hydroquinone cream (Bi-Coastal Pharma International LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/07/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Hydroquinone (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 07/07/2016.

Disclaimer: This information is independently developed by MIMS based on Hydroquinone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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